Goal Concentrations — Gentamicin/Tobramycin
Select a target to fill Desired Peak and Desired Trough, or edit the fields manually for local protocol.
Targets use institutional aminoglycoside dosing ranges; indication examples are bedside context, not a substitute for culture data or local protocol.
Patient Data START HERE
yr
L/kg
mL/min
When to use this field Enter an alternate CrCl only when you have a better patient-specific dosing estimate than the calculated Cockcroft-Gault value, such as measured CrCl, 24-hour urine, cystatin-informed assessment, or a protocol-specified renal estimate. Lee-Dang may be used as a chronic spinal cord injury estimate for vancomycin or aminoglycoside dosing; do not apply it as a universal renal-function rule.
Dosing Targets
mcg/mL
mcg/mL
Results
Initial regimen planning
Calculated Starting RegimenModel An Alternate Regimen
Dose — mg
Interval q—h
Infusion —
SS peak — —
SS trough — —
Initial load — —
Initial loading amounts assume no residual drug. Calculated interval: —. Population-estimated aminoglycoside clearance and Vd may not predict individual PK accurately; consider earlier levels when clinically appropriate to assess clearance and preempt accumulation. Change the interval, then calculate the dose for that interval.
Aminoglycoside dosing — for use by licensed clinicians. Equations: K = 0.0024(CrCl)+0.01 (Matthews 1995; Bauer 2014); V = 0.26 L/kg (Sarubbi & Hull 1978). Cockcroft-Gault CrCl is used unless an optional alternate CrCl is entered for dosing. Adults only — the weight and clearance estimates here are not validated in patients under 18. Dialysis and unstable renal function need dosing by measured level, not by an estimated clearance. Verify against institutional protocol.