Goal Concentrations — Gentamicin/Tobramycin
Standard infections (intra-abdominal, UTI): Peak 5–7 mcg/mL · Trough <2 mcg/mL
Difficult-to-penetrate / high MIC (pseudomonal pneumonia): Peak 8–10 mcg/mL · Trough <2 mcg/mL
Gram-positive synergy (endocarditis): Peak 3–4 mcg/mL · Trough 0.5–<1 mcg/mL
Difficult-to-penetrate / high MIC (pseudomonal pneumonia): Peak 8–10 mcg/mL · Trough <2 mcg/mL
Gram-positive synergy (endocarditis): Peak 3–4 mcg/mL · Trough 0.5–<1 mcg/mL
yr
L/kg
mcg/mL
mcg/mL
Results
| Parameter | Value | Unit |
|---|
—
mg every —h · infused over —
| Estimated Level | Value | Unit |
|---|
Aminoglycoside dosing — for use by licensed clinicians. Equations: K = 0.0024(CrCl)+0.01 (Matthews 1995; Bauer 2014); V = 0.26 L/kg (Sarubbi & Hull 1978); Cockcroft-Gault CrCl. Adults only — the weight and clearance estimates here are not validated in patients under 18. Dialysis and unstable renal function need dosing by measured level, not by an estimated clearance. Verify against institutional protocol.