Patient & renal labs START HERE
yr
for Cockcroft-Gault
mg/L
auto-selects by BMI

Click CALCULATE to get CrCl / eGFR

Enter values and hit Calculate — results appear here.
Target & regimen AUC-GUIDED
Clearance source: none yet — run the Renal tab, or enter CL manually below
yr
actual body weight
from renal driver · mL/min
mL/min
target mg·h/L
mg·h/L
mg/kg
population clearance 0.75 × CrCl + 4 (ml/min)
volume of distribution 0.29×age + 0.33×wt + 11 (L)
Enter values and hit Calculate — results appear here.
Current regimen & level SS TROUGH
per dose
dosing frequency
per dose
min
steady-state Css
mcg/mL
yr
target mg·h/L
mg·h/L
actual body weight
population volume 0.29×age + 0.33×wt + 11 (L)
Level timing
Last dose given
:
Trough drawn
:
Next dose due
:

Confirm steady state: 4–5 half-lives elapsed, stable renal function, the dose that established this trough given on time (±1 h).

Enter values and hit Calculate — results appear here.
Regimen & two levels TWO LEVELS
per dose
dosing frequency
per dose
min
post-distribution
mcg/mL
end of interval
mcg/mL
Level timing
Dose start
:
Peak drawn
:
Trough drawn
:
Enter values and hit Calculate — results appear here.

TheraCALC — for use by licensed clinicians. Scope: stable, non-dialysis renal function. Recommendations are generated using the proprietary TheraIQ engine developed and maintained in-house. TheraCALC does not rely on any third-party clinical decision-support service. First-order one-compartment estimates — verify against institutional protocol and clinical context. AUC24 400–600 for serious MRSA; sustained >650 raises nephrotoxicity risk. Population CLv models were derived from Cockcroft-Gault CrCl; eGFR drivers are de-indexed to BSA and run off-calibration.

v2.71  ·  2026-08-13